MR ASAP
WP Leaders: Bart van der Worp (UMC Utrecht) and Paul Nederkoorn (Amsterdam UMC)
Aim: To assess whether the treatment with glyceril trinitrate, started within 4. Hours after symptom onset in the prehospital setting, improves outcome in patients with AIS or ICH.
MR CLEAN-LATE
WP Leaders: Robert van Oostenbrugge (Maastricht UMC) and Wim van Zwam (Maastricht UMC)
Aim: To evaluate the safety and efficacy of Endovascular treatment in acute ischemic stroke in patients with a proven anterior circulation intracranial occlusion, a small infarct core and moderate to good collaterals and last seen well between 6-24 hours before enrollment.
MR CLEAN-MED
WP Leaders: Aad van der Lugt (Erasmus MC) and Diederik Dippel (Erasmus MC)
Aim: To assess the safety and effect of unfractionated heparin and platelet inhibitors, alone or in combination, in patients with acute ischemic stroke, wo undergo endovascular treatment for a confirmed anterior circulation occlusion.
MR CLEAN-NOIV
WP Leaders: Charles Majoie (Amsterdam UMC) and Yvo Roos (Amsterdam UMC)
Aim: To assess the effect of direct endovascular treatment compared with intravenous thrombolytic treatment followed by EVT (when indicated), in patients with acute ischemic stroke, caused by CTA confirmed anterior circulation occlusion.
DUTCH ICH pilot
WP Leaders: Karin Klijn (Radboud UMC) and Ruben Dammers (Erasmus MC)
Aim: To assess the the safety, feasibility and technical effectiveness of minimally-invasive endoscopy-guided surgery within 8 hours of symptom onset for treatment of supratentorial intracerebral hemorrhage (ICH). Additionally, the DUTCH ICH Surgery Trial – pilot study intends to estimate the potential effect of minimally-invasive endoscopy-guided surgery on functional outcome in patients with supratentorial ICH.
