Closed trials

MR CLEAN trial

Click here form the MR CLEAN pages


Click here for the MR PREDICTS decision tools

MR CLEAN Registry

Click here for the MR CLEAN registry pages


WP Leaders: Bart van der Worp (UMC Utrecht) and Paul Nederkoorn (Amsterdam UMC)

Aim: To assess whether the treatment with glyceril trinitrate, started within 4. Hours after symptom onset in the prehospital setting, improves outcome in patients with AIS or ICH.

Click here for the MR ASAP website


WP Leaders: Robert van Oostenbrugge (Maastricht UMC) and Wim van Zwam (Maastricht UMC)

Aim: To evaluate the safety and efficacy of Endovascular treatment in acute ischemic stroke in patients with a proven anterior circulation intracranial occlusion, a small infarct core and moderate to good collaterals and last seen well between 6-24 hours before enrollment.

Click here for the MR CLEAN-LATE website


WP Leaders: Aad van der Lugt (Erasmus MC) and Diederik Dippel (Erasmus MC)

Aim: To assess the safety and effect of unfractionated heparin and platelet inhibitors, alone or in combination, in patients with acute ischemic stroke, wo undergo endovascular treatment for a confirmed anterior circulation occlusion.

Click here for the MR CLEAN-MED website


WP Leaders: Charles Majoie (Amsterdam UMC) and Yvo Roos (Amsterdam UMC)

Aim: To assess the effect of direct endovascular treatment compared with intravenous thrombolytic treatment followed by EVT (when indicated), in patients with acute ischemic stroke, caused by CTA confirmed anterior circulation occlusion.

Click here for the MR CLEAN-NOIV website


WP Leaders: Karin Klijn (Radboud UMC) and Ruben Dammers (Erasmus MC)

Aim: To assess the the safety, feasibility and technical effectiveness of minimally-invasive endoscopy-guided surgery within 8 hours of symptom onset for treatment of supratentorial intracerebral hemorrhage (ICH). Additionally, the DUTCH ICH Surgery Trial – pilot study intends to estimate the potential effect of minimally-invasive endoscopy-guided surgery on functional outcome in patients with supratentorial ICH.

Click here for the Dutch ICH pilotwebsite