MR CLEAN NOIV IRIS

IRIS: Improving Reperfusion strategies for Ischemic Stroke

Individual patient data pooled meta-analysis of six randomized controlled trials on the value of intravenous recombinant tissue plasminogen activator (rtPA) administration prior to endovascular treatment (EVT), for acute ischemic stroke caused by anterior circulation large vessel occlusions.

The trial team of MR CLEAN-NO IV is collaborating with the trial teams of DIRECT-SAFE, DEVT, DIRECT-MT, SKIP, and SWIFT DIRECT on an individual patient data pooled meta-analysis, in order to achieve the most accurate estimate of the value of intravenous rtPA prior to EVT. Further updates on this follow-up project of the MR CLEAN-NO IV trial will be posted on this webpage, in addition to the News page.

IRIS Statistical Analysis Plan

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IRIS Principal Investigators, per participating trial team

DIRECT-MT:
Prof. Jianmin Liu, MD, PhD, Changhai Hospital, China
Prof. Pengfei Yang, MD, PhD, Changhai Hospital, China
Prof. Yongwei Zhang, MD, PhD, Changhai Hospital, China

DEVT:
Prof. Wenjie Zi, MD, Xinqiao Hospital, China
Prof. Raul Nogueira, MD, Emory University School of Medicine, Georgia, USA
Qingwu Yang, MD, PhD, Xinqiao Hospital, China

SKIP:
Prof. Kentaro Suzuki, MD, PhD, Nippon Medical School Tokyo, Japan
Prof. Kazumi Kimura, MD, PhD, Nippon Medical School Tokyo, Japan
Yuji Matsumaru, MD, PhD, University of Tsakuba, Ibaraki, Japan

DIRECT-SAFE:
Prof. Bernard Yan, MD, PhD, The Royal Melbourne Hospital, Australia
Prof. Peter Mitchell, MD, PhD, The Royal Melbourne Hospital, Australia
Zhongrong Miao, MD, The Royal Melbourne Hospital, Australia

SWIFT DIRECT:
Prof. Urs Fischer, MD, PhD, Universitätsspital Basel, Switzerland
Prof. Jan Gralla, Inselspital Bern, Switzerland
Johannes Kaesmacher, MD PhD, Inselspital Bern, Switzerland

MR CLEAN-NO IV:
Prof. Charles Majoie, MD, PhD, Amsterdam UMC, the Netherlands
Prof. Yvo Roos, MD, PhD, Amsterdam UMC, the Netherlands
Kilian Treurniet, MD, PhD, Amsterdam UMC, the Netherlands
Manon Kappelhof, MD, PhD, Amsterdam UMC, the Netherlands
Fabiano Cavalcante, MD, Amsterdam UMC, the Netherlands

Data and Imaging committee

Steven Bush, MD, The Royal Melbourne Hospital, Australia
Lei Zhang, MD, Changhai Hospital, China
Prof. Kentaro Suzuki, MD, PhD, Nippon Medical School Tokyo, Japan
Prof. Jan Gralla, Inselspital Bern, Switzerland
Prof. Urs Fischer, MD, PhD, Universitätsspital Basel, Switzerland
Johannes Kaesmacher, MD PhD, Inselspital Bern, Switzerland
Prof. Charles Majoie, MD, PhD, Amsterdam UMC, the Netherlands
Kilian Treurniet, MD, PhD, Amsterdam UMC, the Netherlands
Manon Kappelhof, MD, PhD, Amsterdam UMC, the Netherlands
Fabiano Cavalcante, MD, Amsterdam UMC, the Netherlands

Statisticians

Prof. Hester Lingsma, PhD, Erasmus MC, the Netherlands
Prof. Leonid Churilov, PhD, University of Melbourne, Australia
Daan Nieboer, PhD, Erasmus MC, the Netherlands

Contact

Fabiano Cavalcante, PhD candidate/neurologist, f.cavalcante@amsterdamumc.nl
Manon Kappelhof, postdoc/Radiology resident, m.kappelhof@amsterdamumc.nl
Kilian Treurniet, postdoc/Radiology resident, k.m.treurniet@amsterdamumc.nl