WP3b – Carotid artery stenting during endovascular treatment for acute ischemic stroke (CASES)


WP leaders: Maarten Uyttenboogaart (UMCG) & Paul Nederkoorn (AUMC)
PhD: Theodora van Elk (UMCG), Louise Maes (UZ Leuven)



The workpackage

The hypothesis of the Carotid Artery Stenting during Endovascular treatment for acute Stroke (CASES) trial is that immediate carotid artery stenting (CAS) of an ipsilateral high grade carotid artery stenosis during EVT for acute ischemic stroke is non-inferior compared to EVT with deferred treatment of carotid artery stenosis.


Primary objective
To assess the efficacy of immediate CAS among patients with acute ischemic stroke treated with EVT and a severe ipsilateral proximal carotid artery stenosis (>50%) or occlusion and compare this with the current routine care strategy of EVT with a deferred treatment (including best medical treatment without CEA/CAS) of the proximal carotid artery stenosis according to the guidelines.

Secondary objective
To compare the safety of the two strategies (immediate CAS versus deferred treatment) regarding the incidence of symptomatic intracerebral hemorrhage, recurrent stroke, and early proximal carotid artery re-occlusion.

Tertiary objective
To compare quality of life and cost-effectiveness of both strategies.